The eccentric Chanel designer claimed last month that Adele was "a little too fat" when he guest-edited a French magazine.
But Madonna, 53, stuck up for the Grammy-winner, hitting back, "That's horrible. That's ridiculous, that's just the most ridiculous thing I've ever heard.
"I don't like it when anybody says anything bad about anyone - I don't like it. Adele's a great talent and how much she weighs has nothing to do with it."
Madonna, who won seven Grammys and two Brit awards, explained how she sustained a career in music spanning more than a quarter of a century - and said it is decent advice for Adele, 23, to stay on the right track.
She said, "The thing for Adele to remember is at the end of the day, whether you rise or fall, it has so much to do with how you sustain yourself and keep your integrity and your inner strength.
"It is all about who you surround yourself with - friends and people who really do care about you, and care about your well-being beyond being a superstar. That's the most important thing."
The Material Girl also spoke about the deaths of two of the brightest female solo stars in the past six months.
Amy Winehouse died last July aged just 27 after suffering a public battle with drugs and alcohol.
Then last month Whitney Houston was found dead in her hotel bath in the Beverly Hilton in LA. She was 48.
Madonna said, "I, probably like everybody else, was hit by this shocking sense of disbelief - especially with Whitney Houston.
"It had not been a secret, the struggles Amy had been through - both brilliant, brilliant artists and obviously both huge losses.
"But when these things happen, I'm always shocked by the first thing you say - 'It's such a loss' - which doesn't quite cover it.
"We've lost so many great artists that way when you think about it. So history just kind of repeats itself over and over."
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