May 19, 1995 // Madonna's "Human Nature" music video premiered on MTV.

The music video premiered on May 19, 1995 through MTV. It features Madonna, her dancers, and her chihuahua, Chiquita, in black leather and latex outfits. Madonna's look and outfit for this video is "latex and leather" to symbolize the "breaking out of the restraints". Her hair, which appears brown in the video was actually blonde at the time. She had leather strips painstakingly braided into her hair to blend with her dark roots. The frizzy afro she sports halfway through the video was actually a hairpiece. As the video concludes there is a shot of Madonna sitting in a chair, looking straight into the camera as she says the line "Absolutely no regrets!". Then there is a brief shot of her standing next to the chair as she boxes into the air.

Louis Virtel from The Backlot ranked the video at number 22 on a list for "Madonna's 22 Best Videos, In Honor of Her 55th Birthday", and called the video "tongue-in-cheek, pleather-heavy". He went on to say that "It's rare that Madonna gets a chance to be both harsh and hilarious in a music video", and in this one, "Madonna basically does whatever the hell she wants. Brandish a chihuahua? Mock and celebrate kinkiness? Sneer at the camera like a bored third-grader? She does it all, and even in black cornrows, she's a vision of coolness and sexual superiority". Carol Vernallis fromExperiencing Music Video: Aesthetics and Cultural Context noted that the concept of black outfit against a white background "works well, but the snare drum, which corresponds to nothing in the imagery, seems to float above the soundtrack". In 2011, Rihanna's controversial "S&M" was compared to "Human Nature"'s music video, as blogger Perez Hilton said, "It reminded me of Madonna during the 'Erotica' phase and the 'Hollywood'/ 'American Life' phase, both of which were controversial".